Background: Fabrication of the composite scaffold was carried out by combining chitosan, gelatin, and B-tricalcium phosphate (BTCP) derived from limestone. The extraction of BTCP was based on the abundance of limestone containing calcium carbonate, which can be a source of BTCP synthesis. Purpose: This study evaluates the degradation of the combination of chitosan–gelatin (ChG) and chitosan–gelatin–BTCP (ChG-BTCP) composite scaffolds. Methods: The freeze-drying method was used to obtain the composite scaffold, which was a mixture of chitosan, gelatin, and BTCP. Degradation was measured by immersing the samples in a simulated body fluid solution at 37 C for 3, 7, 14, and 21 days. For statistical analysis, one-way analysis of variance (ANOVA) and post hoc Fisher’s least significant difference were performed. Results: The ChG scaffold shows better degradability than the ChG-BTCP scaffold. The ChG scaffold shows higher weight degradation than the ChG-BTCP scaffold up to 21 days. Conclusion: In conclusion, the scaffold containing BTCP has lower degradation than the ChG scaffold.
Oleh :
Tansza Permata Setiana Putri
